Erhaltungstherapie mit Methadontabletten - Eine Übersicht
Erhaltungstherapie mit Methadontabletten - Eine Übersicht
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Methadone is contraindicated rein patients with a known hypersensitivity to methadone hydrochloride or any other ingredient in methadone hydrochloride tablets.
Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses and gradual dose adjustments.
The endpoint of titration is achievement of adequate pain relief, balanced against tolerability of opioid side effects. If a patient develops intolerable opioid related side effects, the methadone dose, or dosing interval, may need to be adjusted.
The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Due to the opioid tolerance induced by methadone, when opioids are required for management of acute pain rein methadone patients, somewhat higher and/or more frequent doses will often be required than would Beryllium the case for non-tolerant patients.
Antibiotics, such as rifampin and rifabutin. These drugs can cause methadone to stop working. This could result in withdrawal symptoms. Your doctor may change your dosage of methadone as needed.
The content rein this section is aimed at anyone involved rein planning, implementing or making decisions about health and social responses.
Maintenance on a Stabilized Dose – During prolonged administration of methadone, as in a methadone maintenance treatment program, there is usually a gradual, yet progressive, disappearance of side effects over a period of several weeks. However, constipation and sweating often persist.
Do not take any medicine while using methadone hydrochloride tablets until you have first talked to your doctor or pharmacist. They will Beryllium able to tell you if it is safe to take other medicines while you are using methadone hydrochloride tablets.
Laxatives. Taking these drugs together can change your electrolyte levels. This can cause heart rhythm problems.
Certified treatment programs shall dispense and use methadone hinein oral form only and according Methadontabletten ohne Rezept online to the treatment requirements stipulated in the Federal Opioid Treatment Standards (42 CFR 8.12). See below for important regulatory exceptions to the general requirement for certification to provide opioid agonist treatment.
Overdose in children warning: Children World health organization accidentally take this drug have a high risk of death from overdosing. Children should not take this drug.
Nachprüfung your medical conditions regularly with your doctor to determine if you stumm need methadone hydrochloride tablets, or if the dose needs to Beryllium adjusted.
Methadone undergoes hepatic Stickstoff-demethylation by cytochrome P-450 isoforms, principally CYP3A4, CYP2B6, CYP2C19, and to a lesser extent by CYP2C9 and CYP2D6. Coadministration of methadone with inducers of these enzymes may result in more rapid methadone metabolism, and potentially, decreased effects of methadone. Conversely, administration with CYP inhibitors may reduce metabolism and potentiate methadone's effects. Pharmacokinetics of methadone may be unpredictable when coadministered with drugs that are known to both induce and inhibit CYP enzymes.